b'Forging New Research in Pediatric Cancer FORGING NEW RESEARCH IN PEDIATRIC CANCER BIOMEDICAL LIFECYCLE MODELBIOMEDICAL LIFECYCLE MODELFor children who have been diagnosed with pediatric cancers, few things feel quite as preciousCRADLE-TO-CAREER-TO-CUREF CRADLE-TO-CAREER-TO-CUREo or rc ahsil fdrraegnil ew h oa sh tahveefbueteunr ed. iagnosed with pediatric cancers, few things feel quite as The Biomedical Lifecycle Model is PCRFs holistic framework to transform the pediatric cancer landscape. It ensures children with preciousor as fragileas the future.\x1fe Biomedical Lifecycle Model is PCRFs holistic framework to transform the pediatric cancer landscape. It ensures In the past 43 years, Pediatric Cancer Research Foundation (PCRF) has invested more than $61 million to accelerate cures and improvecancer not only receive treatment today but benefit from innovative research, a sustainable workforce, and lifelong support for n children with cancer not only receive treatment today but benet from innovative research, a sustainable workforce, Itr etahtem peanstt o 43p tyieoanrs fs, Poer cdihatilrdich Cooand ccear nRceesr pearacthie Fnotus. Dndeastpioitne m (PCaRkFin) g sihasg innivecsatnet pd mroogrere tshsa, tnh $e l61a smtinillg eion teoc tas occef tleoraxtic te chuereras paineds, c imhrporonvic heealthmental health and survivorship care tomorrow.tro and lifelong support for mental health and survivorship care tomorrow.c eantdimteionnt so, aptniod pnss fyocrh cohloildghicoaol sdt rceasnscoerrs c paotnietinunts.e t Deo pspiotsee li mafeklionngg c sighnaifillceanngte s tproo sgruresvs,i vthoers a lasntd tingh eeffir fecatms oilif etso. xic therapies, chronic health conditions, and psychological stressors continue to pose lifelong challenges to survivors and their families.Leading the Way with New Institutional Priorities Institutional Priorities: Leading the Way with New Institutional PrioritiesTo address these issues, PCRF has implemented three new guiding institutional priorities Powering Research, Equitable Care, Survivorship & Mental HealthTo address these issues, PCRF has implemented three new guiding Institutional Priorities: 1. Powering ResearchFunding Innovations That Save Lives and Improve Quality of LifeIn the U.S., pediatric cancers remain the leading cause of death from disease among children ages 1 to 14. Of those that survive, 60-90% will develop one or more chronic health conditions. \x1de most common types of cancer among children and adolescents dier by age group, race and ethnicity. \x1dats why we are prioritizing research targeted in these areas:Rare cancers with low survival ratesMore eective and less toxic treatment options to minimize negative side eectsExpand clinical trial support for the most prevalent cancers within specic age groups, races, and ethnicities to address disparities in cancer incidence and outcomes 2. Equitable Care Ensuring All Children Have Access to the Treatments They NeedChildren diagnosed with cancer who live in rural or socioeconomically disadvantaged neighborhoods face signicantly higher mortality rates relative to those without either factor.* \x1dese disparities are further exacerbated by dierences in race, ethnicity, socioeconomic, and geographic location. To ensure that all children have equitable access to pediatric cancer research, treatment, and care, we are prioritizing these areas:Expand clinical trials that specically target diverse populationsLeveraging technology and AI to enhance treatment outcomesSupport family nancial programs to have access to care Long-Term Systems Change vs. Single-Focused Initiatives*NIH, ncbi.nlm.nih.govCRADLEEARLY FOUNDATIONS 3. Survivorship and Mental Health Support Invest in education & scholarships Inspire youth & survivors to enter pediatric oncologyEmpowering Children to Live Fullling LivesBuild pipeline of future clinicians, healthcare and research careersChildren who are undergoing or have undergone cancer treatment often endure immense physical, emotional, andCUREpsychological challenges. \x1de stress of frequent hospital visits, painful procedures, and social isolation can lead toBREAKTHROUGHS & SURVIVORSHIPsignicant mental health issues, including depression and anxiety, both during and long after treatment. Moreover, Accelerate research via innovation and grantspediatric cancer survivors face unique and ongoing challenges that extend beyond their medical treatment, including long-term health issues, learning disabilities, and signicant nancial strain. Expand partnerships across education, healthcare, and biotechExpand survivorship & mental health programsGiven the shortage of resources, PCRF is investing in these areas:Mental health needs of childhood cancer patients CAREERResearch to reduce both short- and long-term eects SUSTAINING THE WORKFORCEPsychosocial programs to ease the emotional and psychological burden of the diseaseFund Emerging Investigator Grants Survivorship programs to support the next generation of college graduates and future oncology specialistsSupport early-research career developmentInvest in direct patient care, research and mental health professions7'