b'Dear Friends,As I reflect on this past fiscal year, I am filled with gratitude for your generosity, passion, and steadfast commitment to children and families facing pediatric cancer. Together, we have made extraordinary progressin a time when the need has never been greater.Pediatric cancer remains one of the leading causes of death by diseasein children, yet it receives less than 4% of federal cancer research funding.At the same time, the pediatric oncology workforce is shrinking, creatinga crisis that threatens both research progress and patient care.Against these challenges, this year marked Pediatric Cancer Research Foundations (PCRF) most successful yet. Our community came together like never beforeachieving new benchmarks in funds raised, expanding our Survivor Scholarship program, and launching our bold $25 million campaign: Powering Cures, Realizing Futures. We also introduced new Institutional Priorities and the Biomedical Lifecycle Model, a holistic strategy that ensures we not only fund groundbreaking science, but also strengthen the workforce andexpand survivorship and mental health support so children canthrive long into the future.The results are already visible. Weve advanced innovative research and care programs, welcomed new donors and partners, and brought greater awareness to the urgent need for action. Behind every number and milestone are children and families whose lives are touched by your compassion.The future ahead is one of determination and hope. With your partnership, PCRF is advancing a path toward equity, cures and lasting impact, because every child deserves more than survival. They deserve the opportunity to dream, grow, and live fully. Thank you for standing with us. Together, we are powering cures and realizing brighter futures for children everywhere.With gratitude,Danielle Fragalla, MSEChief Executive Officer5'